Application status of the hottest neutral glass in

2022-08-02
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The application status of neutral glass in the field of pharmaceutical packaging (Part 1)

international neutral glass is commonly called class I glass, and some in China call it 5.on glass or class a material. This kind of glass has been widely used in the field of pharmaceutical packaging because of its good material and performance, especially its excellent chemical stability and thermal stability. At present, the international neutral glass has been widely recognized by the international pharmaceutical packaging market, except that a few countries such as China and India have not fully adopted it. After China's entry into the WTO, China's pharmaceutical industry will face a situation of full integration with the international market. In order to speed up the integration of China's drugs and their packaging materials with the international standards and the international market as soon as possible, resist the huge impact brought by the entry of international pharmaceutical products and packaging products into the Chinese market, ensure the safety and effectiveness of drug packaging, and ensure people's health, The process of actively promoting the use of international neutral glass in the field of pharmaceutical packaging has become an urgent major issue

I. development overview of international neutral glass at the end of the 19th century, the development of modern medicine urgently needs a glass container that can be stored with the liquid medicine for a long time without chemical reaction. Its main requirements are: the long-term contact between the glass container and the liquid medicine will not cause the change of pH value, and there will be no precipitation or glass chips falling off. Therefore, this kind of glass is called neutral glass, This kind of glass was invented by Schott company in Germany in 1910. Subsequently, the United States, Japan and other countries invented and produced one after another. With the continuous development and improvement of glass manufacturing process, the application field of pharmaceutical neutral glass is expanded and its performance is more perfect. Since the 1950s, many enterprises in China have introduced production equipment, processes and technologies from advanced countries in the world, such as Schott company of Germany, neg company of Japan and Corning company of the United States. However, limited to the national conditions at that time, when we-c universal machine was operated, sometimes a slight noise would be generated if we did not pay attention to it. Due to the problems such as low qualification rate, high cost, low product price and manufacturing technology, especially the market chaos The development, production and application of international neutral glass in China have not been effectively solved and popularized for various reasons such as the domestic market is ahead of schedule. In the 1960s, due to the rapid development of the domestic pharmaceutical industry, the demand for injection glass container packaging increased sharply. Domestic enterprises developed and produced low borosilicate glass, commonly known as grade B material, which could basically meet the requirements for the use of drugs at that time. Because this kind of glass material adapted to domestic production equipment and processes, with low cost and high output, it basically met the demand for China's drug output at that time, Therefore, this kind of glass has been used in China until now, which has become an important reason why Chinese medicinal glass can not be in line with international standards. Although this kind of glass has played a historic role in promoting the development of pharmaceutical packaging, in essence, this kind of glass can only be a substitute for the degradation of grade, quality and performance of pharmaceutical neutral glass. In the face of today's international market of economic integration, the rapidly developing pharmaceutical industry, an endless stream of new and special drugs, and people's increasing pursuit of life and health, China's pharmaceutical glass industry should develop and produce international neutral glass that can be in line with international standards as soon as possible, and gradually limit and eliminate the low borosilicate glass that has been used in China

II. International standard and performance of neutral glass

international standard ISO normally mass-produced glass is clearly divided into three types according to composition classification and test methods:

1 borosilicate glass

linear thermal expansion coefficient of this glass cc: (3.3 soil 0.1) × 10-6k-1 (20-300 ℃) its chemical composition SiO, 81%b, O 12-13%r o 4%alo, 2--3%

2 neutral glass

the linear thermal expansion coefficient of this glass cc: (4--5) × 10-6k-1 (20-300 ℃) its chemical composition is: SiO, 75%b, O 8-12%r o 4--8%ro 5%alo, 2--7%

3 soda lime glass

the linear thermal expansion coefficient of this glass cc= (8--10) × 1 see the copper material passing through the base ldquo; Melting pot rdquo; The chemical composition of the latter 0-6k-1 (20-300 ℃) is: SiO, 70--75%r, o12-16%ro 10-15%ai2o3 0.

5--2.5%

among the three glass materials with ideal effects, the inner surface of the glass container made of soda lime glass has certain chemical properties after surface neutralization treatment, but the water resistance test of the particle method can not meet the requirements of class I glass. Borosilicate glass has excellent resistance to temperature change and good chemical stability in 2020. However, this kind of glass has a high softening point and requires a high flame temperature when sealing i:1. It is difficult to seal ampoules for water injection. It is mainly used to make tube bottles for freeze-drying agent because its heat-resistant impact performance is better than neutral glass. Neutral glass has excellent chemical properties and is widely used in the packaging of various injections, blood, vaccines and other drugs. It is a widely used medicinal glass material in the world, and it is also the main glass material with which China's medicinal glass should be connected as soon as possible

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